Scientific Studies

Backed by Research. Not by Hype.

Scientific Studies

Red light therapy is one of the most studied, non-invasive modalities in regenerative medicine. Light is not new, it's biology. Below you’ll find peer-reviewed research exploring photobiomodulation for skin health, inflammation, muscle recovery, wound healing, hair growth, and veterinary applications.

At Helio Aesthetics, we believe informed wellness is powerful wellness.

Human Clinical Research

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A prospective,randomized, placebo-controlled, double-blinded and split-face clinical study on LED photo therapy for skin rejuvenation (clinical, periocular wrinkles)
A single-blinded randomized controlled study to determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation.
The Effects of Low-Level Laser Therapy on Wound Healing and Pain in Skin Wounds: A Systematic Review and Meta-Analysis.
The Efficacy of Low-Level Laser Therapy on the Healing of Oral Wounds: A Systematic Review
Visible Light in the Treatment of Acne Vulgaris (review of clinical outcomes with red/visible light).
Unlocking the Power of Light on the Skin (broad dermatologic PBM review including acne parameters).
Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter Randomized, Sham Device-Controlled, Double-Blind Study.
Effectiveness of Photobiomodulation in Reducing Pain and Improving Disability in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.
Photobiomodulation Therapy in Carpal Tunnel Release: A Retrospective Cohort Study.
Photobiomodulation of Pain in Carpal Tunnel Syndrome (review of controlled trials).
Mechanisms and Applications of the Anti-Inflammatory Effects of Photobiomodulation.
Mechanisms and Applications of the Anti-Inflammatory Effects of Photobiomodulation (expanded review).
Reprogramming Macrophage Phenotypes With Photobiomodulation: Implications for ENT-Related Inflammatory Disorders.
A Single-Blinded Randomized Controlled Trial Assessing the Effect of Photobiomodulation Therapy on Neuron-Specific Biomarkers in Type II Diabetes Mellitus Patients With Peripheral Neuropathy.
Photobiomodulation Therapy Proved Effective in Reducing Neuropathic Pain and Associated Symptoms in DPN Patients (RCT abstract).
Effects of Photomodulation Therapy for Delayed Onset Muscle Soreness: Systematic Review and Meta-Analysis.
Effects of Photomodulation Therapy for Delayed Onset Muscle Soreness (open-access article with quantitative results).
Photobiomodulation in Human Muscle Tissue: An Advantage in Sports Performance? (review).
Photobiomodulation Therapy With Light-Emitting Diode Does Not Improve Lower-Body Muscle Performance and DOMS in Resistance-Trained Men (negative RCT).
Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy.
Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation.
Brain Photobiomodulation Therapy: A Narrative Review.
Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder: A Double-Blind, Sham-Controlled, Pilot Study.
Transcranial and Systemic Photobiomodulation for Major Depressive Disorder: A Systematic Review of Efficacy, Tolerability and Biological Mechanisms.
Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Hypothyroidism (Randomized Clinical Trial).
Low-Level Laser Therapy in the Treatment of Autoimmune Hypothyroidism (Randomized, placebo-controlled clinical trial—overview/presentation).
Photobiomodulation Improves Histological Parameters in Testes and Increases Testosterone Production (preclinical).
Photobiomodulation Is More Effective Than Long-Term Exercise in Treating Progressive-Type PCOS in Rats (reports increased Leydig cells/testosterone; preclinical).

Veterinary Clinical Research

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Photobiomodulation therapy on canine elbow osteoarthritis — randomized, blinded, placebo-controlled trial
Photobiomodulation therapy in dogs with hip osteoarthritis — randomized, double-blinded controlled trial
Retrospective clinical evaluation of laser therapy in canine osteoarthritis
Effect of photobiomodulation therapy on synovial inflammation following TPLO surgery
PBM therapy in canine post-operative rehabilitation for thoracolumbar disc extrusion
High-intensity laser therapy photothermal effects on equine superficial digital flexor tendon
Influence of low-level laser therapy on equine metacarpal wound healing
Assessment of wound area reduction in chronic wounds treated with 830 nm PBMT
Low-Level Laser Therapy on wound healing and pain in skin wounds - systematic review and meta-analysis
Class IV therapeutic laser on post-surgical wound healing in dogs and cats
Prospective blinded study of fluorescent PBM on surgical incisions in dogs
PBM effects on wound healing biology and collagen formation — mechanistic review
Photobiomodulation therapy for canine elbow OA (inflammatory modulation context).
Systematic review of photobiomodulation in veterinary medicine.
Low-Level Laser improves functional recovery in rat sciatic nerve crush injury.
PBM vs HILT comparison in sciatic nerve regeneration.
Experimental rodent inflammatory pain model demonstrating PBM analgesic effects.
Fluorescent light energy for canine superficial bacterial folliculitis.
PBM for pyotraumatic dermatitis (“hot spots”) case series.
830 nm low-level laser therapy penetration efficacy in cats.
Chronic pain & bone healing in a cat following laser therapy.
Clinical review of PBM applications in veterinary dermatology.
Effects of low-power laser irradiation on bone healing — meta-analysis.
Osteoporotic rat model showing improved bone repair with PBM.
PBM mitigates cardiovascular aging and increases longevity in mouse model.
Near-infrared light improves mitochondrial function in aged mice.
Transcranial low-level laser therapy improves mitochondrial function in aging mouse model.